Danny Willett won a tournament for the first time since becoming Masters champion in 2016 at the DP World Tour Championship, while Francesco Molinari wrapped up the Race to Dubai title.
Willett suffered a loss of form following his unexpected triumph at Augusta but held off the challenge of fellow Englishman Matt Wallace and reigning Masters champion Patrick Reed, with whom he shared the overnight lead, to come away with the victory.
The 31-year-old finished two shots clear of Wallace and Reed on 18 under par, despite bogeys at holes 10 and 12.
Molinari finished in a tie for 26th, but Tommy Fleetwood's failure to win the event - ending the weekend in 16th - was enough to see the Italian end the season as Europe's number one golfer.
Wallace joined Willett at the summit following the eventual winner's quickfire bogeys, but three birdies across the last five holes were enough to re-establish the cushion.
Reed struggled to keep pace with Willett on Sunday and was two over through the front nine.
He managed five birdies and a bogey after the turn but his efforts were not enough to elevate him back to the top of the leaderboard.
Jon Rahm, Adrian Otaegui and Dean Burmester were a further two shots adrift of Wallace and Reed in a tie for fourth.
Molinari's triumph brings to a close a season in which he won The Open and the BMW PGA Championship.
The 36-year-old was also one of the stars of Europe's victory in the Ryder Cup, forming a formidable pairing with Fleetwood that became known as 'Moliwood'.
Molinari, finishing the tournament six under par, becomes the first Italian to top the European Tour's money list.
"It's incredible," said Molinari. "Now I'm going to have time to sit down and relax and really think back about the last few months.
"This morning on the first tee the announcement is the winner of The Open Championship, Race to Dubai leader, it doesn't sound real at the moment.
"It's more than I ever dreamed of achieving. I've seen guys that I think are better players than me not winning majors and not winning Order of Merits or Race to Dubais. To achieve those things in one single season is just incredible."
18. Dezember 2018
|Mourinho sacked: 895 days and more than £700,000 in five-star luxury|
|Es Tunis 1 Guadalajara 1 (6-5 on penalties): Dhaouadi holds nerve to settle ill-tempered affair|
|Murphy lands permanent Tigers role|
|Mourinho sacked: Real Madrid´s Marcelo lauds ´great coach´ after United exit|
|Unadkat, Varun the top buys at IPL auction|
|Emery prepared to give youth a chance in north London derby|
|Tottenham extend Vertonghen contract until 2020|
|Panthers safety Reid receives seventh random drug test of 2018|
|Kovac relishing Klopp challenge in Champions League|
|Bancroft to return, teenager Lamichhane to fly the flag for Nepal in Big Bash|
|Liverpool still have plenty of work to do - Klopp|
|Messi ´never imagined´ his success after winning record fifth Golden Shoe|
|WATCH: Timberwolves´ Gibson tries to block shot with his trainer|
|Mourinho sacked: Klopp praises departed Manchester United boss|
|Mourinho sacked: Jose the best Manchester United manager since Ferguson - Gerrard|
|Mourinho sacked: Ferdinand calls for ´fresh ideas´ at Man United|
|Mourinho sacked: The mystique has gone as United spell ends in divorce|
|´He´s an interest not only for us but for many´ - Zola praises rumoured Chelsea target Wilson|
|Mourinho sacked: Pochettino focused on Spurs amid Manchester United rumours|
|Mendis eyes double-century for departing Samaraweera|
|Mourinho sacked: Zola expects Jose to be in another job ´soon´|
|Mourinho sacked: Five reasons it went wrong at Manchester United|
|Mourinho sacked: Jose´s Manchester United record in Opta stats|
|Mourinho sacked: Pogba, Ronaldo and Jose´s biggest bust-ups|
|Mourinho sacked: Blanc, Solskjaer - the men who could steady the United ship short-term|
|Mourinho sacked: The football world reacts|
|Mourinho sacked: What former United stars said after Liverpool loss|
|Mourinho sacked: Where next for the axed Manchester United boss?|
|UEFA to investigate alleged racist incidents at Vidi-Chelsea|
|Australia unchanged for rest of India series|
|Mourinho sacked: Pogba´s tweet a dig at departing Man United boss?|
|Newton left frustrated by shoulder injury as Panthers lose again|
|Mourinho sacked: Pochettino & Zidane lead potential Man Utd replacements|
|Mourinho sacked: Neville urges Man United to go for Pochettino|
|Boylen pleased to see Bulls react to red rag in Thunder fracas|
|Icardi and Inter ´very far´ apart in contract negotiations|
|Mourinho leaves Manchester United|
|Curry humbled by latest milestone|
|Robertson: ´Unbelievable´ Alisson will bounce back from error|
|Curry scores 15,000th regular-season point in Warriors win|
|Rams star Gurley ´day-to-day´ with knee inflammation|
|Saints poised to clinch NFC top seed after topping Panthers|
|Mathews, Mendis centuries frustrate New Zealand|
|Kohli: Relentless Australia deserved victory|
|Relief for Paine and Australia after ending Test drought|
|Australia level series with dominant win over India|
|Libertadores holders River learn group as CONMEBOL boss calls for end to violence|
|Chargers RB Gordon planning to return against Ravens|
|Kobe Bryant visit motivated Browns´ Jabrill Peppers|
|De Bruyne: Fatigue not behind injury woes|
|´That´s not my concern´ - Broncos coach Joseph on job security|
|Lowry on Leonard´s free agency: I just want him to be happy|
|Yankees give Sabathia $500K bonus despite ejection|
|Ronaldo confirmed Juventus interest in January – Mendes|
|Lakers guard Rondo to begin rehab stint in G League|
|Saiz to leave Leeds United for Getafe|
17. Dezember 2018
|Whyte thinks Joshua rematch is ´only a matter of time´|
|Greenwood stars as Man United end Chelsea´s FA Youth Cup dominance|
|Panthers tight end Olsen expects ´full recovery´ after surgery|
|Derby County 0 Nottingham Forest 0: Lampard´s men fourth after tense stalemate|
|Clermont lose former All Black Toeava for six months|
|MLS unveils revamped playoff format for 2019 season|
|Ferrari to celebrate Schumacher´s 50th birthday with museum exhibition|
|Rabiot set for PSG exit after cancelling contract talks|
|Pepe departs financially troubled Besiktas|
|Philadelphia Flyers fire coach Dave Hakstol|
|Eagles to start Foles v Texans|
|PSG matches against Montpellier and Dijon rearranged|
|Martial agent clouds long-term future after United trigger extension|
|Zverev to make major final in 2019, predicts Ferrero|