Ben Morgan has been recalled to the England squad for the November internationals but there is no place for Danny Cipriani in a 36-man squad which includes eight uncapped players.
Morgan has not played for his country since the 2015 World Cup, but the number eight is set to make his comeback next month amid an injury crisis.
Billy Vunipola and Sam Simmonds are ruled out with a fractured arm and a serious knee injury respectively, while Nathan Hughes is unavailable for the first three Tests after being hit with a six-week ban.
Mako Vunipola, Chris Robshaw, Joe Launchbury, Jonathan Joseph and Anthony Watson were among the other players that Eddie Jones was unable to call upon.
"We can only control what we can control and injuries have happened," Jones said in an RFU statement.
"It gives an opportunity for some good new players to play some important Tests for England while players who have been in the squad before, will have to take on more responsibility.
"I'm really happy with the squad."
Fly-half Cipriani misses out for the matches against South Africa, Japan, New Zealand and Australia despite an impressive start to his Gloucester career.
Dylan Hartley and Owen Farrell have been named as co-captains, while Joe Cokanasiga, Nathan Earle, Ted Hill and Zach Mercer will be hoping to earn their first caps.
Ben Moon, Michael Rhodes, Nick Schonert and Elliott Stooke are the other uncapped players in a squad that will fly out to Portugal for a training camp next week.
Forwards: Tom Curry, Charlie Ewels, Jamie George, Dylan Hartley, Alec Hepburn, Ted Hill, Maro Itoje, George Kruis, Courtney Lawes, Zach Mercer, Ben Moon, Ben Morgan, Michael Rhodes, Nick Schonert, Brad Shields, Kyle Sinckler, Elliott Stooke, Sam Underhill, Harry Williams, Mark Wilson.
Backs: Chris Ashton, Mike Brown, Danny Care, Joe Cokanasiga, Elliot Daly, Nathan Earle, Owen Farrell, George Ford, Alex Lozowski, Jonny May, Jack Nowell, Henry Slade, Ben Te'o, Manu Tuilagi, Richard Wigglesworth. Ben Youngs.
16. November 2018
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|Low praises ´beautiful goals´ from Sane and Gnabry|
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|Rooney convinced England are in safe hands with Southgate|
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|Republic of Ireland 0 Northern Ireland 0: Randolph saves light up bore draw|
|England 3 United States 0: Experimental side impresses on Rooney farewell|
|Croatia 3 Spain 2: Jedvaj keeps World Cup finalists in contention|
|Belgium 2 Iceland 0: Batshuayi rekindles Hazard flame with match-winning brace|
|Germany 3 Russia 0: Sane on target as Low´s men stroll|
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|Green: Altercation with Durant will make Warriors stronger|
|Juventus star Dybala dismisses Manchester United links|
|Strinic given all clear to return to AC Milan training|
|Papier wait over as scrum-half starts for Springboks|
|MLB commissioner Manfred gets five-year extension|
|South Africa international Du Preez joins brother at Sale|
|Pogba and Sterling support my football dream, says Bolt|
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|New team tournament ATP Cup wins Djokovic´s approval|
|Roma and Pallotta donate €150,000 to injured Liverpool fan Sean Cox|
|England captain Root reprimanded on frustrating day in Pallekele|
|Jokanovic proud of establishing Fulham´s ´footballing identity´|
|Huget to make first France appearance in a year|
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|Petaia and Gordon to make Wallabies debuts in Padova|
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