Serena Williams and her comeback was cut short by sister Venus at Indian Wells, while world number two Caroline Wozniacki survived.
Playing her first competitive tournament since the 2017 Australian Open, 23-time grand slam champion Serena fell to Venus in straight sets on Monday.
Joining Venus in the fourth round was Australian Open champion Wozniacki, who was less than convincing in the desert.
Meanwhile, defending champion Elena Vesnina was bundled out by Angelique Kerber earlier in the day.
VENUS OUTSHINES SERENA
While all eyes were on Serena, Venus stole the show in her 6-3 6-4 victory.
Venus, the eighth seed, was a class above in the 29th meeting between the Williams sisters – Serena boasting a 17-11 head-to-head record before the blockbuster clash.
The seven-time major winner defeated Serena for the first time since 2014, while claiming her first straight-sets win against her youngster sister since 2008, despite a late stumble.
Venus was leading 5-2 when she wasted a match point and the 37-year-old needed to fend off a break point in the 10th game before closing it out.
WOZNIACKI MUDDLES THROUGH
It was far from convincing as Wozniacki prevailed 6-4 2-6 6-3 against Aliaksandra Sasnovich.
Wozniacki overturned a 4-1 deficit in the opening set as she reeled off five successive games to take the lead.
The Danish star could not stop Sasnovich in the second set, however, as a decider loomed.
But Wozniacki managed to compose herself, regrouping after dropping the opening game before progressing.
Wozniacki, who will face 20th seed Daria Kasatkina for a spot in the quarter-finals, said: "I was struggling finding my rhythm. I didn't really feel comfortable out there today. Didn't really get my game going the way I wanted to."
KERBER DETHRONES VESNINA
Vesnina's title defence was ended by two-time grand slam winner Kerber, who triumphed 7-5 6-2.
After losing the first four games of the match, Vesnina responded by winning five on the bounce for a chance to serve for the set.
But Vesnina never earned a set point as Kerber overcome a marathon first set – saving break points and reeling off the final three games.
The second set was more straightforward for Kerber, who will now play Caroline Garcia in the last 16 after the Frenchwoman eliminated Daria Gavrilova 7-5 6-4.
"I know what to expect. I played against her at the end of last year," Kerber said. "It's another quite big match for me, and I will go out there, try to play like I played the last weeks and try to enjoy the next match."
Reigning US Open champion Sloane Stephens and fourth seed Elina Svitolina were among those to bow out.
20. Juni 2018
|Ronaldo bearing down on Daei after going past Puskas - The top five goalscorers in international foo|
|Portugal 1 Morocco 0: Record-breaker Ronaldo sends Renard´s men out|
|Halep pulls out of Eastbourne International|
|Brazil v Costa Rica: Coutinho ready for more Selecao toil|
|Muller and Bierhoff dismiss reports of German disharmony|
|Mooy can play at a higher level, says Socceroos boss Van Marwijk|
|Remarkable Ronaldo breaks Puskas´ European record|
|Belgian Grand Prix deal agreed until 2021|
|Isco: I´m not going to speak to Ronaldo again!|
|Slater expects to be fit for Origin II|
|Curran and Overton added to England ODI squad|
|Hussey fears Australia will be left with ´mental scars´|
|Fabianski swaps Swansea for West Ham|
|Loftus-Cheek ready to replace Alli|
|England are a team now - Rashford|
|Lazaridis calls for Cahill to start against Denmark|
|Arzani and Ryan can play at the highest level, says Bosnich|
|Dust (Ja)pan and brush: Blue Samurai fans clean up in Saransk|
|Lodge reaches agreement over New York attack|
|Gerrard can become a strong manager - Arena|
|Arsenal target Torreira has left for €30m, says Sampdoria chief|
|Murray unsure over Wimbledon participation|
|De Gea has to bounce back from Ronaldo shocker - Bosnich|
|Martinez not looking for perfection|
|Farah´s Wests Tigers return confirmed|
|Cubs get extra-inning win to split doubleheader with Dodgers|
|Denmark will ´struggle´ if Australia stop Eriksen, says Jakobsen|
|Astros´ win streak ends at 12|
|Lahm backs Germany, Low after losing start|
|Messi has all our support – Dybala|
|Strickland apologises for ´stupid decision´ that led to broken hand|
|Five-time Open Championship winner Thomson dies aged 88|
|´Positive´ Pogba not bitter towards media, says Varane|
|Portugal privileged to have ´humble´ Ronaldo, says Pepe|
|Strickland breaks hand punching door after blown save, out for up to eight weeks|
|He will have received good money – Costa delighted by Griezmann extension|
|Kane: Pochettino sent me love hearts after World Cup heroics|
|Nationals place Adams on 10-day DL with broken finger|
|Dybala: I can play alongside Messi|
|Lewandowski: Poland didn´t take enough risks|
|England´s Kane aiming to reach Ronaldo, Messi levels with World Cup performances|
19. Juni 2018
|Kicker given three-year match-fixing ban|
|England confirm Alli thigh injury|
|Federer through, Zverev out in Halle|
|Back on the map and earning letters from ladies, Tabarez embraces Uruguay´s heritage|
|Rampant England rout Australia in record-breaking display|
|Pulisic in right place at Dortmund, says Arena|
|Wilshere confirms Arsenal exit|
|NASCAR at Sonoma: TV schedule, standings, qualifying drivers for Toyota/Save Mart 350|
|Muguruza and Kvitova cruise through in Birmingham|
|Leno among top 10 most expensive goalkeepers|
|Pained Salah unable to halt Russia´s unlikely march|
|Kyrgios downs ´legend´ Murray as Dimitrov and Djokovic progress|
|Neymar pain normal – Coutinho unconcerned by ankle issue|
|Russia 3 Egypt 1: Salah strikes but hosts right on course for last 16|
|We must make Ronaldo less exceptional, says Morocco boss Renard|
|Chandimal handed one-Test ball tampering ban, faces further ICC charge|
|Arsenal sign goalkeeper Leno from Leverkusen|
|Mexico style in Germany win surprised Arena|
|Monaco complete €20m move for Lyon teenager Geubbels|
|Saudi team don´t know cause of aeroplane fire, Pizzi reveals|
|Champions League qualifying draw: Celtic travel to Armenia, Ajax face Sturm Graz|
|I´ve never seen a player win on his own – Santos shrugs off Ronaldo dependence|
|Murray impresses despite narrow defeat on return|
|West Ham land club-record Diop signing|
|El Hadji Diouf hails ´perfect start´ for Senegal|
|Cisse and Senegal give cause for African celebration|
|Carvajal ready to face Iran - Hierro|
|Japan´s World Cup victory over Colombia sparks celebrations on the streets of Tokyo|
|Poland 1 Senegal 2: Good fortune and bad errors hand Africans Group H win|