The amount of teams in the market for a quarterback means this could be one of the most important drafts of recent years.
In a decade's time, the 2018 draft will likely be looked back on as one that altered the course of a number of franchises for better or worse.
As well as organizations looking for a quarterback, there are a number of teams aiming to take the next step for whom this draft is similarly crucial.
Here we assess the five teams with the most riding on the 2018 NFL Draft.
The only way is up after an 0-16 season and, with the first and fourth overall picks at their disposal, as well as three selections in the second round, this is a golden opportunity to add premium talent to a team that general manager John Dorsey cannot afford to miss.
Surely even Cleveland cannot mess this one up. History, and rumors of an apparent infatuation with Wyoming quarterback Josh Allen, suggests otherwise.
New York Jets
Mike Maccagnan does not have much prior credit with the Jets' fanbase, particularly after wasting a second-round pick on Christian Hackenberg in the 2016 draft, and has no room for error this year.
After trading up to get to the third overall pick, missing on a quarterback with that selection would set the franchise back into the next decade and likely cost Maccagnan his job.
Green Bay Packers
"We'd be very happy and content taking a quarterback at that spot."— New York Jets (@nyjets) April 24, 2018
GM Mike Maccagnan's pre-draft press conference pic.twitter.com/bIDLikGJ3g
Aaron Rodgers would have you believe that talk of his discontent at the Packers' personnel moves is exaggerated, but what cannot be denied is that Green Bay need to stop wasting one of the best quarterbacks of all time.
Rodgers can elevate his supporting cast on offense to another level, but the Packers still lack talented pass rushers and traded away one of their best defensive backs in Damarious Randall.
If they cannot make improvements on the front seven and in the secondary in this draft it will likely be another year without a Lombardi Trophy for Rodgers.
San Francisco 49ers
Trading for the man billed as Tom Brady's successor has so far paid huge dividends and, with the Jimmy Garoppolo deal and an impressive first draft on his resume, John Lynch already has a strong reputation as a GM.
But Garoppolo can only take the 49ers so far. It is the defense that will decide to what extent the 49ers will compete in 2018. Kyle Shanahan can scheme up an offense for Garoppolo to excel in regardless of the talent around him but, for the 49ers to succeed, Lynch needs to find defensive prospects who can take an improving unit to the next level.
He has four picks in the top 75 with which to do so. Should he fail then some of the shine will be taken off the early part of his tenure and life will be more difficult for the Niners in a loaded NFC.
New England Patriots
With Garoppolo gone, and continued murmurings about the future of Brady, the Patriots need a succession plan again.
There has long since been talk of Bill Belichick wanting to secure his legacy by leaving the Patriots with a quarterback in place.
They have two first-round picks with which to find a new successor to Brady, potentially via a trade, but the Patriots still need pass rush help and also lost talent in the secondary, as well as left tackle Nate Solder and running back Dion Lewis, in free agency.
This is a draft in which the Patriots need to secure their long-term future at quarterback and have plenty of more immediate holes to fill. For Belichick, it is the most important draft since the one that netted Brady 18 years ago.
16. Januar 2019
|Panthers owner Tepper doesn´t rule out Newton missing 2019 because of shoulder injury|
|De Ligt will be world´s best centre-back – Koeman|
|Ronaldo a ´perfect machine´, says Gattuso|
|Barcelona? I can´t say anything - Stuani|
|Silva upbeat about Man City title chances|
|Celtics youngsters say Irving´s callout ´came from a good place´|
|NFL playoffs: Patrick Mahomes v Tom Brady|
|NFL playoffs: Jared Goff v Drew Brees|
|Sixers sign Brewer to 10-day contract|
|Lozano and Morgan scoop CONCACAF awards|
|Lakers ´optimistic´ about LeBron injury|
|Giants produce mammoth fourth quarter against Nymburk|
|Austin FC to join MLS in 2021|
15. Januar 2019
|Henry, Vieira look forward to reunion when Monaco host Nice|
|Barcelona reject Neymar phone call reports|
|Wentz is the quarterback ´going forward´, says Eagles coach Pederson|
|Gattuso: Higuain has not asked to leave|
|Drew Brees by the Opta numbers: 10 facts for QB´s milestone birthday|
|Harry Kane injury: England captain´s history of ankle woe|
|Harry Kane injury: Opta numbers suggest Spurs struggles|
|Harry Kane injury: Tottenham´s options in striker´s absence|
|Allegri: Supercoppa clash practice for Champions League knockouts|
|First in clean sheets, second to Schmeichel in titles – Cech´s Premier League career in Opta numbers|
|Warrington sign England star Widdop|
|Gatland confident Wales can win Six Nations|
|Fulham sign Netherlands international Babel|
|Harry Kane injury: Games the Tottenham striker will miss|
|Simeone focused on matches, not transfer dealings|
|Iran v Iraq: Pressure off for Queiroz & Katanec|
|Vietnam v Yemen: Kocian keeps the faith|
|Darren Bravo back in West Indies Test side for first time since 2016|
|Kane out until March with ankle injury|
|South Korea v China: Son arrives for Group C dead rubber|
|Kyrgyzstan v Philippines: Eriksson remains hopeful|
|McGrath to miss Six Nations, Sexton nearing fitness|
|Kohli savours Dhoni ´classic´|
|Ford: People obsess over Farrell fly-half battle|
|EFL asks Leeds to explain ´spygate´ scandal|
|No alarms for Djokovic and Zverev, Raonic masters Kyrgios|
|Australia 3 Syria 2: Rogic breaks hearts with stoppage-time winner|
|Palestine 0 Jordan 0: Socceroos winner keeps hopes alive for Lions of Canaan|
|Halep: The results don´t matter any more|
|Hard work for Halep as Serena and Osaka sail through|
|Napoli director to take legal action over ´false´ quotes about Rog move|
|Alexander-Arnold facing absence of up to four weeks|
|Solari: We only have one number nine at Real Madrid|
|Halfpenny & Young named in Wales´ Six Nations squad|
|Crawford v Khan confirmed for April 20|
|Centurion Kohli inspires India to level ODI series|
|Wagner hails Huddersfield togetherness after exit|
|Hughes to join Bristol, Le Roux also leaving Wasps|
|ICC appoints Sawhney as new CEO|
|Forest appoint club legend O´Neill as new manager|
|Halep digs deep to gain revenge over Kanepi|
|Cech to retire at the end of the season|
|Brisbane Roar 0 Melbourne Victory 5: Barbarouses treble sinks Roar|
|´Struggling´ Azarenka breaks down in tears following Australian Open exit|
|Dominant Djokovic coasts through in Melbourne|
|Allardyce admits Huddersfield appointment is ´highly unlikley´|
|Choupo-Mouting: Manchester United have changed|
|Faletau set to miss Six Nations with another broken arm|
|UEFA opens disciplinary proceedings into Chelsea chants|
|Serena´s the greatest ever - Bouchard relishing second-round clash|
|Mbappe can become the new Pele - Pele|
|Wade needs to learn quickly if he´s to make NFL switch a success, says Sanu|
|Azarenka beaten in first Australian Open match since 2016|
|Kings use balanced scoring attack to top Trail Blazers|
|Hewitt laughs off Tomic criticism|
|We love Ederson the way he is - Guardiola on Man City´s sweeper keeper|
|Serena: The greatest win of my career|